According to BBC News, the Liverpool station at Crosby is one of eight centres across the United Kingdom set to be shut as part of the British Government's reorganisation of the national coastguard network.
Twenty jobs are expected to be lost in the closure, which could see the base for the UK Maritime Operations Centre move to England's South Coast.
Liverpool coastguard currently covers the area in North West England from the Dee Estuary to the Mull of Galloway in Scotland, as well as much of the Irish Sea beyond the Isle of Man.
Last weekend alone it responded to 56 incidents in a 48-hour period.
Local staff have expressed fear that consolidation will see the region served by coastguards with no familiarity with the area.
A spokesperson for the Maritime and Coastguard Agency (MCA) reiterated Shipping Minister Mike Penning's intention to "to create a resilient and fully networked national rescue co-ordination service".
The Liverpool coastguard e-petition is available via the campaign website at SaveLiverpoolCoastguard.org.